Implen NanoPhotometer®, the #1 NanoDrop Alternative

Implen is a privately held corporation that is a leading supplier for spectroscopy instruments and consumables for the non-destructive analysis of ultra-low volume samples. The company focuses on biological, chemical, and pharmaceutical laboratories in industry and research. Implen has a strong focus on the customer taking pride in providing quality products and a high level of customer service to achieve total customer satisfaction. In 2006 we launched the NanoPhotometer® product line to introduce the first NanoDrop alternative. The NanoPhotometer® today is the most trusted NanoDrop alternative.

NanoPhotometer® Family Main Features

implen microvolume nanophotometers spectrophotometers NanoDrop alternative main features

Precision & Lifetime Accuracy Guaranteed

Since 2006 Implen has been pioneering and spearheading the UV/Vis micro volume spectroscopy market by continuously introducing new industry standards in the field. Implen was the first to offer:

  • Microvolume and cuvette option in one instrument
  • Stand-alone operation (built-in computer)
  • 21 CFR part 11 Compatibility
  • Full scan and analysis of 12 samples in 20 seconds
  • Maintenance and recalibration free operation
  • Ability to also measure organic solvents in a drop
  • Integrated blank and sample purity control (help to comply with MIQE guidelines for qPCR experiments)
  • Built-in vortex
  • Built-in Web Application Server with REST API for full integration in LIMS systems and lab networks
  • Mobility (battery option)

and more…

 

NanoPhotometer® Models    Compare to NanoDrop

Today thousands of users at universities, research institutions, government agencies, hospitals, biotech and pharma companies in more than 100 countries trust the Implen NanoPhotometer® every day with their precious samples in research, quality control and manufacturing for the main applications of nucleic acids (DNA, RNA, Oligo), Protein UV, Protein Assays (Bradford/BCA), OD600 and sample purity (260/280 and 260/230 ratios).

More than 9,000 peer-reviewed scientific articles have been published citing the Implen NanoPhotometer®. A comparison between the Nanodrop One, the NanoPhotometer® NP80 and other technologies for the analysis of human genomic DNA and oligonucleotide samples can be found in the following publication from the National Institute of Standards and Technology (NIST) "Limitations of methods for measuring the concentration of human genomic DNA and oligonucleotide samples."

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Compare to NanoDrop One / One C

The table below demonstrates a comparison of the Nanodrop One/One C vs. the NanoPhotometer® line of spectrophotometers

FeaturesNanoDrop One / One C Implen NanoPhotometer® N60/NP80
Instrument Performance
Minimum Sample Volume1 µL
2 µl sample size is recommended for protein measurements
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0.3 – 2 μL
Pathlength 0.03 – 1 mm
Auto-ranging
Recalibration recommended by manufacturer
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Utilizes two fixed path lengths 0.67 and 0.07 mm
Fixed path lengths never change over the lifetime of the instrument
Measurement Time 8 seconds
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2.5 – 4 seconds
(full scan 200 – 900 nm)
Enclosed Sample Measurement SurfacesNO

Column is exposed to surroundings, leading to sample evaporation.
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YES
Enclosed sample measurement surfaces
No evaporation
Accurate results independent from environmental conditions
Ability to measure proteins with detergent buffers without sample build-up
Photometric Range Cuvette 0 – 1.5 A implen nanodrop alternative checkmark
0 – 2.6 A
Organic Solvents N/A implen nanodrop alternative checkmark
Enabled
Detection Range* dsDNA: 2 – 27,500 ng/µl
BSA: 0.06 – 820 mg/ml
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dsDNA: 1 – 16,500 ng/µl
BSA: 0.03 – 478 mg/ml
Optical Specifications
Measurement Wavelength Full scan from 190 – 850 nmimplen nanodrop alternative checkmark
Full scan from 200 – 900 nm
Illuminated Read HeadN/Aimplen nanodrop alternative checkmark
Illuminated read head for an easy sample application
Light SourceXenon Flash Lampimplen nanodrop alternative checkmark
Xenon Flash Lamp
Instrument Features
Maintenance-freeNO

Thermo Fisher Scientific recommends performing a Calibration Check using CF-1 calibration check fluid every 6 months and regular service every year
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YES
No recalibration
No reconditioning
Maintenance-free over the entire lifetime
Reconditioning-freeNO

The pedestal of the instrument may become unconditioned over time, especially when measuring proteins or samples that contain surfactants or detergents. This requires reconditioning of the unit’s pedestal.
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YES
Scratch-resistant inert quartz pedestal that requires no reconditioning
Quality Control Warnings Acclaro Technology with contaminate calculationsimplen nanodrop alternative checkmark
Sample Control™: quality control technology identifies sample impurities, potential contaminants, turbidity and lint residue
Blank Control™: prevents inaccurate readings caused by high background blanks or insufficient cleaning
Built-in Web Application Server NO

Limited Android-based internal computer only
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Full Web Application Server with REST API
21 CFR part 11 By external computer only implen nanodrop alternative checkmark
Stand-alone and by external computer
Processing Power, Compatibility, Data Processing
Operating SystemAndroidimplen nanodrop alternative checkmark
Linux based NPOS (NanoPhotometer Operating System)
Open platform to connect to Windows, Mac OS, Android, iOS via web application interface
Onboard Processor Quad Core
ARM Cortex
A9 Processor
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Built-in computer with high-performance Intel Celeron dual core 2.4 GHz processor
Internal Data Storage 32 GBimplen nanodrop alternative checkmark
32 GB for storage of thousands of measurements
Software Compatibility Compatible with Windows onlyimplen nanodrop alternative checkmark
Compatible with Windows 7, 8, 10 (32 and 64 bit), Mac OS X, iOS and Android OS
Data Transfer and Connectivity OptionsThe unit includes 3x USB A, Ethernet, Bluetooth, WiFiimplen nanodrop alternative checkmark
The unit includes 2x USB A, USB B, HDMI, Ethernet, WiFi
Data OutputSeparate as .csv .tsv .sqlimplen nanodrop alternative checkmark
Complete data as PDF & Excel
Instrument Control The device can be connected to a computer via USB cable for operation, control and data storage.
implen nanodrop alternative checkmark
Easy control of the NanoPhotometer is possible via Wi-Fi from tablets or smartphones (Android OS & iOS). Control from PCs via LAN, WiFi or USB (Windows & Mac). The HDMI port allows for presentations directly from the device.
WiFi Hotspot Client possibleimplen nanodrop alternative checkmark
Built-in WiFi hotspot and with WiFi client capability
Instrument Dimensions20 × 25.4 × 32.3 cm
(8 × 10 × 12.7 inches)
20 x 20 x 12 cm
(7.9 x 7.9 x 4.7 inches)

* dsDNA tends to precipitate/coagulate at concentrations above 10,000 ng/µl and should be diluted.

Implen's Overcoming Limitations of Other Technologies

Have you experienced any of these difficulties with your current technology?

  • Inconsistent protein readings (caused by a drop rupture/low surface tension)
  • Instability of drops (caused by used up hydrophobic condition of pedestal)
  • Costly recalibration/maintenance or decreasing accuracy over time
  • Instrument's service and support discontinued and software not compatible with Windows10 or Mac OS
  • Low reproducibility (mainly caused by evaporation effects)
  • Device cannot be cleaned with ethanol and/or operated under laminar flow
  • Getting results for more than 40 samples per run is time consuming
  • No user management/21 CFR part 11 compliant software available
  • Waited for weeks to get instrument repaired
other-technologies-instruments-difficulties

 

How about trying a device that overcomes all of these issues?

implen nanophotometers number one nanodrop alternatives N120 NP80 N60 C40

NanoPhotometer® Models    Request a Quote

Implen NanoPhotometers® Reviews

"Great results and very accurate!"

Rating: 5.0   ★★★★★

Application Area: Protein assays and concentrations

"I love love love this machine. It's portable, idiot proof, and accurate. For its DNA analysis, it is much more accurate than the old familiar, Nanodrop. I love the fact that it is so modifiable and easy to use. We use it for a variety of functions in the lab, including Bradford assays. I really love that there is a built-in graph for these and that you can email it to yourself or save on a USB stick. This machine is the thing we have all been needing but never knew we missed. Also the customer care is outstanding and I look forward to our rep every time she comes."

Andrea Kuipers
Organization: California Institute of Technology

"Awesome machine. I would purchase another one for additional labs."

Rating: 5.0   ★★★★★

Application Area: Genetics Academic Laboratory - Microarray Core

"I love the dynamic range for RNA/DNA measurements. We did our own in house check for reproducibility. The interface is very user friendly and easier to use than nanodrop. We like that we can use 1 ul of precious sample for an accurate reading rather than the required 1.5ul for nanodrop. I am in the midst of uploading the newest upgraded software so I will test it out and give additional feedback. This has been a god-send. We have very low concentration samples that are very precious and this allows us to make measurements on these types of samples. Also, after doing PCR amplification, we no longer have to make dilutions for the upper limit readings due to the large dynamic range."

Twyla Juehne
Organization: Washington University School of Medicine

"Great accuracy of measurements, easy usage, really nice interface."

Rating: 5.0   ★★★★★

Application Area: determination of the concentration of proteins and nucleic acids solutions

"C40 NanoPhotometer is a great tool to measure macromolecule concentrations in microvolumes. It surpasses our previous nanodrop machine as it does not need calibration and has more functions. Easy interface is a great advantage and the new function of enzyme kinetics together with vortex makes this small and handy tool a multitask help in our lab. The wi-fi functions enables us to print spectra quickly. Measurements are repeatable and accurate. I would recommend the equipment every biochemistry lab."

Joanna Sliwiak
Organization: Institute of Bioorganic Chemistry, Laboratory of Protein Engineering

"Ease of use and accuracy for a reasonable price!"

Rating: 5.0   ★★★★★

Application Area: Neurosciences

"The Implen N50 is the perfect solution for my DNA/RNA spectrophotometry needs. The batch export feature is great, and includes both an aggregate spreadsheet with all samples listed as well as all data curves in separate tabs. And you can't beat the price; this unit is on par if not better than a Nanodrop for 1/3 the cost!"

Jason Weick
Organization: University of New Mexico

NanoDrop Alternatives from Implen

If you like to learn more about our technology and get an introduction into our range of cutting edge spectrophotometers and its advantages over the Nanodrop approach please get in touch with one of our team or your local distribution partner.

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NanoDrop™ and NanoDrop™ One are registered trademarks of Thermo Fisher Scientific.

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